Induction of Activation-Induced Cytidine Deaminase–Targeting Adaptor 14-3-3g Is Mediated by NF-kB–Dependent Recruitment of CFP1 to the 59-CpG-39–Rich 14-3-3g Promoter and Is Sustained by E2A
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منابع مشابه
Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A.
Class switch DNA recombination (CSR) crucially diversifies Ab biologic effector functions. 14-3-3γ specifically binds to the 5'-AGCT-3' repeats in the IgH locus switch (S) regions. By interacting directly with the C-terminal region of activation-induced cytidine deaminase (AID), 14-3-3γ targets this enzyme to S regions to mediate CSR. In this study, we showed that 14-3-3γ was expressed in germi...
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تاریخ انتشار 2013